 In cats, the incidence of obesity and diabetes is increasing, and there is limited knowledge regarding the endocrine regulation of food intake. Recent studies have suggested that ghrelin plays an important role in the regulation of insulin secretion and vice versa, however this has yet to be confirmed in cats. This study investigated the effects of different nutritional loads on insulin, amylin, and ghrelin levels in overweight cats. It was found that a bolus of glucose or arginine increased insulin and ghrelin levels, while no suppression of ghrelin was observed following the intravenous load of arginine and glucose. Additionally, the absence of arginine-induced suppression of ghrelin suggests that some nutrients may not promote satiety in overweight cats, or that ghrelin may play a role in non-homostatic consumption mechanisms. Further research is needed to determine the exact role of ghrelin in food rewarding cats. This article was authored by Lucille J. M. Martin, Thomas A. Lutz, Caroline Dormers, and others. We are article.tv, links in the description below.