 This study found that congenital scoliosis, CS, is associated with increased levels of fibroblast growth factor 23, FGF23, in the blood, which leads to decreased bone mineral density. Furthermore, this study suggests that FGF23 may be involved in the development of osteopenia in CS patients by regulating the fibroblast growth factor receptor 3, FGFR3, tissue non-specific alkaline phosphatase, TNAP, osteopontin, OPN, signaling pathway. This article was authored by Hon Chi-jong, Geng Xiong, Ji Yong-li, and others.