 COVID-19 is a multi-systemic disease that primarily affects and disrupts the endothelial cells, leading to systemic manifestations. Nailfold videocapolaroscopy, NBC, is a safe, easy, and non-invasive way to assess microcirculatory changes in patients with COVID-19. This review examined the current literature on the use of NBC in patients with COVID-19, both in the acute phase and post discharge. The results showed that NBC can detect significant alterations in capillary circulation, which could be used as a tool to monitor the progression of the disease and its effects on the body. Based on these findings, it is possible to conclude that NBC has great potential to become part of the management of patients with COVID-19, both during and after the acute phase. This article was authored by Lucrezia Mondini, Paola Confallinieri, Ricardo Pottsin, and others.