 The current diagnostic algorithm for acute pulmonary embolism, PE, is associated with the overuse of computed tomography pulmonary angiography, CTPA, which can lead to unnecessary radiation exposure and costly healthcare expenditures. A new highly specific blood test could potentially reduce the number of patients requiring CTPA. This systematic review evaluated the diagnostic performance of eight blood biomarkers in patients admitted to an emergency department with suspected acute PE. Three of the biomarkers showed promising results, but further research is needed before they can be implemented into clinical practice. This article was authored by Varen Irak Statter-Wickin, Birgit Gladso Tondel, Vania Maris Morelli, and others.