 This study found that CCHA's injection resulted in lysis of mature, collagen-rich septa in the subcutaneous layer at an adjacent to the injection site as early as day one after injection. The injection also caused an increase in inflammatory cells and a decrease in hemorrhage from day two to eight post injection. By day 21, new collagen and reorganized fat lobules were observed. Repeat CCHA's injection had similar effects to a single dose. These results suggest that CCHA's injection may be effective for reducing cellulite. This article was authored by Sachin M. Shrigarani, Sojeeva Jayan, Karl M. Napakoski, and others.