 This study developed a novel 3D liver tissue model that mimicked the complex vasculature system and drug-depleted extracellular matrix of human livers. It was used to evaluate the effectiveness of transarterial chemoembolization treatments for primary liver cancer. The model showed that it could accurately predict the success rate of treatments by measuring the amount of drug released from the tumor and how quickly it diffused out of the tumor. This article was authored by Xiaoya Liu, Shuiying Wang, Yu Qingluo, and others.