 An unprecedented injectable stimuli responsive immunomodulatory depot has been reported. That encodes with adenosine triphosphate aptomers and can be intratumorally injected in a gel formulation to induce immunogenic cell death, recruit and activate dendritic cells, enhance tumor immunogenicity, and block the corresponding immune inhibitory checkpoint molecule on tumor cells. This article was authored by Eufan, Mengxi Zhang, Duanhao Yang, and others.