 Prader-Willi syndrome, PWS, is a rare genetic condition caused by a lack of expression of certain genes in the paternal copy of chromosome 15. This leads to physical characteristics such as short stature, hypotonia, and dysmorphic facial features, as well as intellectual disabilities, behavioral abnormalities, and obesity. Previous research has suggested an increased risk of cancer in people with PWS, however this new study shows that the overall frequency of cancer is not increased in the PWS cohort. Instead, they found a higher rate of pediatric cancers including testicular and ovarian tumors. They also discovered a unique case of a germ cell tumor in a patient with PWS, which may provide insight into the potential mechanisms behind the increased risk of cancer in this group. This article was authored by Carolina Mike Gonzalez, Sandra Westman, Sandra Westman, and others.