 The study demonstrates that BUGZ, a co-acervating mitotic effector, promotes intestinal stem cell, ISC, proliferation in drosophila during interphase through age and injury-associated condensation. YT521B, an M6A reader, acts as the transcriptional and functional downstream of BUGZ, and its binding to BUGZ is regulated by promoter and M6A writer Im for Metal 14. The study suggests that phase separation and M6A regulators may be critical for ameliorating ISC-dependent gut regeneration and aging and requires further study. This article was authored by Chao Chao Zhong, Kaideng, Meng Yu Liu, and others.