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Published on Feb 19, 2014
Table of Contents: 00:00 Lecture 4.3: Selectivity: When all else fails, tag, filer and amplify 01:50 Outline 02:20 Classical approach to selectivity 04:05 Increase the signal 05:16 Selectivity: A problem of Information theory? 07:39 Outline 07:44 Centrifuge improves SNR 09:02 Centrifuge isolates components by mass: Svedberg equation 12:13 The final step of differentiation 12:43 Outline 12:54 Idealized Polymerase Chain Reaction (PCR) 14:22 How PCR Doubles DNA Count 16:08 Untitled: Slide 13 16:45 Modeling of PCR reaction: 18:58 Untitled: Slide 15 23:01 Outline 23:42 Selectivity: A problem of Information theory? 23:52 Reduce noise: Optical tag-based sensing 25:21 Magnetic tag-based sensing 27:13 Conclusions
This course provides an in-depth analysis of the origin of the extra-ordinary sensitivity, fundamental limits, and operating principles of modern nanobiosensors. The primary focus is the physics of biomolecule detection in terms of three elementary concepts: response time, sensitivity, and selectivity. And, it potentiometric, amperometric, and cantilever-based mass sensors to illustrate the application of these concepts to specific sensor technologies.