 I'm very honored to be up here co-presenting with someone who very much inspires me and how I think about the whole body, the whole terrain. So, a little bit of our background. We got the great introduction from Miranda, so thank you so much. But basically, a couple things just so you know, because we cover so much information today, we want you to know that there's places for you to gather more information and to keep track of us, because we're going to be doing a lot of trainings and cool things in the near future. So, this is where I begin with every single person that I work with. My 25 plus years in the field of integrative oncology has brought me into understanding ten main things that drive a cantering or chronic illness process. So I have likened it to a big bucket, which you can think of as your mitochondria, and the different things that play into that bucket. The drops of water that fall into that bucket are anything from the microbiome, which we're going to spend time talking about today, stress response and circadian rhythms, metabolic flexibility, so glucose response, hormones, mental emotional things, all of these things add to our bucket at any given time. So when you're talking about cancer, the room usually goes womp, womp, womp. We have to talk about the bad news before we get to the solutions and start talking about what we can do to change the terrain. So I'm going to start with some pretty scary statistics. As you can see up here, by 2030 our cancer rates are expected to double. In this room alone, half of you will likely have cancer in your lifetime. A couple other stats to let them sink in is that just a few months ago in the EU, we now have 12 countries that have cancer as the leading cause of death. That is the first time ever in human history and we're expected to match that statistic by 2020. If you've had cancer, your likelihood of having a recurrence is 70%. So this is why we're having these types of conversations today. I want you to not be that statistic. Let me throw a few more gloom and doom ones out there as we're going to talk about and it'll help you understand why these statistics are so prevalent today is that 80% of all childhood cancers, people who've had cancer in their youth, will have another cancer in their lifetime. That's pretty horrific. And then also the fastest growing rate of colorectal cancer and glioblastomas are in the 25-year-old crowd and younger. And we're also seeing a huge, huge resurgence in leukemia and lymphoma and childhood cancers. Now hopefully this room, I'm preaching a little bit to the choir here, literally you guys look like you're in a choir, is that we can change this and we know the drivers of this. And so we're speaking among colleagues and peers here who can help us get this message out and change these dire statistics. And also if you want to look at the slides, if you go to the Good Institute under media presentations, all our slides are currently loaded up there. And we're going to pull some of the Q&A. So if we run a little bit over, we're going to go to Nation's book signing after and all the Q&A can follow us over there as well. So I just want to let you know that so you don't worry. So I work with clients on gut. It started off with gut and heart disease and then it turns out now pre-cancer cancer. And I always like to look at the footprint of chronic disease and cancer. And when I quizzed my clients, I turned out Nation and I, we had so much in common when I, and then I started just following her all over and stalking her because we do exactly the same thing, whether it's for GI tract or cancer or chronic disease. And when I quizzed clients, it turns out they've had issues ongoing for years, if not decades or even since they were a child. And then they present with two or three autoimmune diseases or severe brain fog or they've recovered from a cancer or two or three. So you kind of get the story. So I love talking about poo, as you know. And one of the first things I ask them is, does it smell? What does it look like? How often do you go? And one of the cases we're going to go over at the end, one was a superstar pooer. But when we quizzed longer, it was never Bristol Four. And Bristol Four is the perfect poo where you have one wipe off the toilet paper, doesn't smear the bowl and doesn't smell very much. It smells like compost, kind of like our farms and happy farm animals. But we have lots of statistics. It's either loose stools or constipation. So the other case we're going to go over, she had three cancer, this case had three cancers by the age of 19, and it was reported a stool bowel movement, constipated bowel movement maybe once a month. So tying it in with irritable bowel syndrome, which is such an epic condition right now, both in kids, teens and adults, there's a huge link and many studies are showing this. For colorectal and rectum cancer, a big association with IBS is 51%. For liver cancer and biliary tract cancer, 40% associated with IBS, irritable bowel syndrome, whether it's constipation dominant or diarrhea dominant. Pancreatic cancer, which is highly on the rise, 56% and kidney 56%. Breast cancer, which is so, we're seeing so much prevalence in our ladies, is also associated, of course. Almost every cancer when I drilled it down, it was. So having more motility means less risk, as much as 46% protection compared to once a day stowing. That was kind of a blow away moment for me, because even our best poopers don't do once a day. I mean, they do once a day, but not more than once a day, without bionic fiber or something like that. And then people who report rare constipation, much less risk. So having much less constipation compared to once a week. And of course, with GI tract conditions, like benign colorectal neoplasm and colorectal cancer, there's a huge risk with chronic constipation, with a relative risk increase of 59% for colorectal, and then with neoplasms as much as 2.6 fold. So why? Again, in this room, most of you know the why, but it's important to point out, because there's a lot of people who will be watching this in the future that this might be the first time they're hearing this information. So before we go into the why, I want to bring a few more pieces of statistics to the forefront to realize also that every single one of us in this room has cancer right now. But the key is that our bodies know how to keep it in check, or they should. And when it goes out of bounds is when we have problems. So again, right now, one in eight women, and probably related to the poo piece here, will have cancer in their lifetime. But also just to know, if you're a woman over 50, you have a 50% chance of already having microscopic breast cancer cells on biopsy. If you're a male over 50, the same is true for prostate cancer. If you're over 70, 100% of people over 70 have microscopic thyroid cancer cells. So please, I tell you that bad news to realize that most of us are walking around with it, but it's not causing a problem right now. So how can we further avoid this? Well, what brought us here are a few key factors. Major, major farming changes. Major especially, I mean, big changes in the 1850s, but we've made major changes since the 1970s when we introduced things like glyphosate, which we'll go into a little more detail about what that causes here in a bit, but also antibiotics in the 1940s, triclosan, a whole slew of other wonderful inventions to make our lives easier in the modern times. But that modern time is not congruent, not synergistic with our ancient microbiome. Our physiology and our anatomy has not changed that much over the past several hundred thousand years, but here we are, that we are trying to kind of overlay our modern lifestyle on an ancient microbiome. So I'll admit again in this room, know this story, but we've had kind of four major iterations of human creation. So what is so fascinating to me is that when you take a look at the poop fossils, that's the thing, and the dental cavities, dental calcifications of this population, these four populations listed up here, we have the highest microbial diversity in the hunter-gatherer group, and the least diverse in the industrial food revolution group revelation as well. And so those main changes, as you can see here, 10,000 years ago before we moved into the Neolithic farming is where we saw one big change. We started to move from fat burners to carbohydrate burners, to sugar burners. Now, fast forward another 9,900 years is when we get to the time where we think it's a good idea to start to process the sugar and flour in our world. So think about how far that had gone, and suddenly we're exploding with really processed sugars, where in the 1850s we were averaging five pounds of sugar per person per year, and in 2014 we're at 175 pounds of sugar per person per year. So hopefully that's showing you that lack of diversity and that metabolic inflexibility is really a big problem. And then when we start to add the things like the wonderful invention of antibiotics that took us from the pendulum of dying of infections to where we started to get to in the last 50 years of dying from inflammation, well this morning one of the speakers talked about, I think it was Guillermo, talked about how we're swinging back to the pendulum of dying infections again. And so that pendulum is swinging wildly and so that's where we are trying to help address that and talk about that. When I look at the gut microbiome, both nation and we run the similar testing. We use functional integrative medicine testing. We culture the stool, we look at the urine organic acids because we can really see what's coming out from the gut because often you can't tell because the colon's only one and a half meters of stool. Really we want to see what's going on in the small intestines. In Japan, they do much research on the gut microbiome, especially babies and adults, and a group of bacteria known as bifido. I call this as one of the integral parts of our ABCs. They combat the bad bacteria and I don't want to give a bad label, but proteobacteria is generally kind of where we see a lot of pathogens. So the deforestation that nation talks about is what we see in the gut now is all kinds of gut testing. And this lack of the ABCs, A is acrimansia, B is the bifido bacterium, it leads to overgrowth. So what studies from Japan and other really prominent gut researchers show is that babies are born with bifido and this is actually the immune system from mom because they have no innate, no adaptive immunity at the time. It's bifido that protects them. And every gut flora that shows up on baby in the beginning has a role, even the equal eye. Where does the equal eye come from on baby? So equal eye is part of proteobacteria and it's also Klebsiella. These are all proteo. And they cover the baby in the beginning. Ear nose throat all the way through. Where does it come from? Poo! Don't be shocked. It's lovely. Especially if it's, you know, Dr. Grace Bristol for poo. And the bifido protects the baby and as we age by three years old, the equal eye and proteo, they've gone down and the reason is they serve a really great role. They eat up the oxygen and then they create that anaerobic vacuum known as the butt. Where we can actually be fermenters and composters, right? And so then the facultative bacteria like the A's, bifido and then lacto and then the C's, they can play into prominence. So when I look at a lot of studies now, all the ABC's are gone. It's terrible. So it's like mom's legacy has not gone down to the baby. And if we were all cars, it'd be like getting a car without a wheel. So let's say you get a car donated by, you know, Uncle John or Auntie Stella. It's like, thanks. You gave me a Tesla, but it's missing three wheels. So now we're seeing all the diseases of aging because of the deforestation of the gut and loss of all these functional modules that all, as humans and other mammals on earth and even insects and birds and boa constrictors, none of us do a lot of work. Our bacteria do it, right? This is the evolution on earth for the last four billion years. So now we're seeing, first time on earth, diseases of chronic conditions are affecting even our children and they're dying before even the parents or the grandparents. So I come back to constipation just because how many of you had constipation before going paleo and ancestral in your diet? I know. It's usually like a third. So finally, we have full genome sequence, full shock on genome sequencing for looking at what is going on in the constipated butt. And usually they're missing a lot of the anti-inflammatory geniuses, like A, B, and Cs. Actually for this study, it was Bacteroides and the Fakali Bacterium, which is part of Clostridialis C. And when I, the nation and I look at studies, we are looking for the overgrows. Where are the viral overgrows? What are they? Is it EBV, HPV, HHV6, Barvo? And what pathogens are we doing? What parasites? What worms? All these are associated with multiple conditions, cancer, chronic diseases, autoimmunity. And what this study was really awesome was the first one where they looked at the loss of functions. There were about 50 functional groups that were different in constipation versus healthy controls. One of the main ones is there was a lot of hydrogen production, methane production, of course, and loss of something called glycerol, or too much, not enough glycerol. And we even use glycerol suppositories for constipation, right? But the main one was actually loss of this function that our gut microbiome did called methyl-glyoxal degradation. And without it, there's oxalates. And you probably heard a talk earlier today by Sally Turner that was amazing about oxalates. The funny thing is most societies on earth that are long living like the National Geographic Longevity Group in Centenarians, they eat a very, very high oxalate diet. The paleo diet is super fucking high oxalates. I'm sorry. So what do we do when we have this loss of function? And how did it happen? Where did the deforestation start to occur? So this is why we're here to figure it out, but antibiotics certainly play a role, stress. A lot of practitioners are in the room. Many of you did residency, killed your adrenals, killed your gut, no sleep, long-call short-calls, right? Moms, right? No sleep, take care, two, three, four babies. Executives, travel, debt lag, right? So we all have some state of some deforestation because that's the Western world. Oxalates are a big deal. They're highly associated with cancer. They actually, in some studies, they say they induce cancer. When we're doing a mammogram, what are we looking at? Calcium oxalate before it turns to hydroxyapatite. And hydroxyapatite's bone, and that's shown that malignant tumors are usually more of the, they've transformed to this bone already. And bone doesn't belong in boobs, right? So how do we prevent this? Do we just go all low, low oxalate and don't eat super food kale? So there's a lot of studies and protocols for oxalates a couple years ago, and they worked so successfully. And we want to look at the terrain that nature talks about, because mercury, copper, all these heavy metals, when they complex with oxalates, they become glass fortresses, shards of glass, and you can't break them down. Mercury oxalates 100,000 times more insoluble than magnesium, magnesium super soluble, and that's why we love magnesium, magnesium citrate for our protocols. So even GI docs now are understanding that chronic constipation is just a sign of the microbiome and probably epigenetic and oxidative stress. So I love nature. When we found each other, like, I just loved her concept because it's no tumor board. Let's talk about the terrain, and that's exactly what I've been really looking at, too. And how do we change the terrain in the easiest way possible, and then how do we get people happy, healthy, and whole again? So here's the bacterial microbiome. Probably many of you are familiar with a lot of these strains now when I talk about them. You know, some of the stats earlier, that we were 10 to 1 bacterial, right? Now it's like 5 to 1, 3 to 1, 2 to 1, 1 to 1. So if we're half hybrid, don't you want the better version? Like, you want the best half of your half, right? You want the best version, version 3.0, 4.0. You don't want to be downgraded by your bacteria, for sure. And if you're missing them, let's bring them back. Let's replenish them and restore function and all the functional modules, including oxalate degradation. And we can do that. And we have so many tools. I'm so grateful for Nation, her training for white mistletoe and the tools in functional medicine, because we can do this, especially with probiotics and prebiotics. So another terrain we don't look at is the vial, viral microbiome, the viral terrain, and the microbiome, which is mycology or fungal terrain. And this often becomes a big picture, especially after antibiotics or stress or C-section or formula, as I mentioned earlier. And we want to look at these because these are actually sources of exogenous oxalates. This is actually not a widely known thing. So we have a lot of aspergillus, saccharomyces, and candida overgrows. Guess where the oxalates come from? From these critters. And so we can change the terrain if they're off and just bring back harmony again. So after disruption today, this weekend Nation and I are staying at a house and previously, before the owners bought it, there were hoarders that lived there. So imagine your house being a hoarder. Like would you allow all that garbage or like right now there's fire sometimes put out. Like poor Seattle, we're dealing with all the smog and smoke right now. Sometimes there's fires to put out. And when there's smoke, we try to get to the source. So when we're missing the ABCs and all the symbiote flora, this is what happens. And all these are known carcinogens. They're just as bad as asbestos, radon, or mercury. And oxalates is one of the big ones. So how do we clean up this terrain? And before we kind of do an overview of the points to drive home in this first section here, is when she talked about the importance of the viroam and their microbiome, just in another statistic, because I like to throw these out to freak you out a little bit and make sure you're awake after lunch, 200,000 cases of Epstein-Barr virus caused cancer worldwide every year. And we don't talk about that. HPV, we've got all these vaccines. By the way, those don't do anything because it's working on just a few strains and it's not changing the terrain. In fact, it's likely making it worse. And so what we're also seeing now is HPV of any strain, vaccinated or not, has a higher risk of things like cervical cancer, obviously we know about, head-net cancers. But many people don't realize it's also a real driver of ovarian cancer. That happens to be a population that I spend the majority of my time with. So just in the take-home message here, there's no one thing ever. There's no one cure. There's no one cause. The terrain is everything. So keep thinking about that bucket. Especially start looking into your own bucket so you don't become that statistic of being half the people in this room getting cancer or have already had cancer in your lifetime. Remember the changes we've made in a relatively short period of time from moving from the hunter-gatherer all the way up to our post-industrial food revolution. And then it's so important that this is why Grace has become a dear, dear friend, is that we're simply a tube with a body wrapped around it. And we need to be tending to that tube a lot because basically you are what you don't poop. And then again to reiterate, when you don't poop, you change your microbiome balance but you also change your metabolic balance. And so moving from fat burners to sugar burners to damaging of our mitochondria, which is the foundation of all chronic illness today. And then again, we've covered the gloom and doom. I could get a little bit of bum, bum, bum. We're going to go into a little bit of hope. So here's that image again. Maybe you can take a little bit deeper and take a little bit deeper look at this bucket now that it has a little different context for you to realize that there's not one thing to look at and don't get seduced by the idea of one treatment or one answer to this either. That can be just as dangerous. So start digging in your own buckets, okay, that's a biggie. Each and every one of us have our own chemically, biochemically, individual, epigenetic, emotional, life experience that is overlaid what goes into that bucket. And so it should also be addressed as such. So after microbiome or fungal biome disruption, we often see insulin resistance. And if you look on this slide, the red is, they're all metabolites of bacteria. Often they're the pathogenic ones. And not only do they make phenol, Cresol, ammonia, and hydrogen and methane gases, but they make all kinds of other, they also make good things. So these are the blue. And this is why it's so important we cultivate our terrain just like a wonderful garden. I think of microbial amplification. We can become the best versions of ourselves as human beings when we have our counterpart, our microbial counterpart as fine-tuned as a car. And as you guys all bring in your car probably every year, right? For tune-up? Or gas change? Or actually I don't do my oil change very often. Don't tell them that. So now we have dashboards. Both Nation and I use pretty similar labs. And I'm expanding to a lot of the labs she uses. And I know Rob Wolf with Wired to Eat. I mean, there's so many metabolic markers that we can now look at. Or a simple testing that we can even do on our own with direct labs. It's amazing. And there's a company I work with now consulting. It's called Viome. We test quarterly and you can see full genome sequencing of your whole microbiome including the fungal elements, the viral, and the bacteria. It's totally new. It's really awesome. And we look at all the organic acids and proteomics and metabolomics right now. We can pick up signatures even before the diseases happen. So as you're fixing your metabolic and restoring metabolic flexibility, the way I kind of think of what Nation does in her book, the metabolic approach to cancer book is that there's a surgery that fixes diabetes like it immediately reverses diabetes and people who are more bitterly obese lose 50 to 100 pounds usually after the first year. They looked at the microbiome and the changes. So the surgery is called Ro and Y gastric bypass. But it's a lot like some of the strategies that Nation uses. So I thought I'd go really quick. But basically they restore microbial diversity. In this study, they looked at 13 more really obese patients who underwent this really ghastly kind of surgery. Yeah, connecting a part of the small intestines. They cut part of the small intestine. So this is why I think it's kind of effective. You have both small intestinal fungal overgrowth and SIBO being excised from there and then shortening the stomach. But they neatly see diversity. And they see a B, the Bifobacterium dentium. They see the A and B and another B called allostypes, it's a bactoroides, come up in prominence and it's statistically significant how much better they are for insulin sensitivity. Also they're able to restore GABA. So a lot of our, the two cases we're going to go over they have GABA mutations just known as GAD1. It's a lot like my clients. I work with executives, multitasking moms and MMA fighters and endurance athletes and some physicians and healthcare practitioners. Everyone's addicted. They're addicted to their lifestyle to being super great, A superstars. They don't have much GABA though. GABA comes from our gut flora. Just like serotonin comes from our gut flora and then we make melatonin. Are we all deficient of Kirk Parsley's sleep cocktail? Which has GABA in it? Pharma GABA. Which is from bacteria. So this study was awesome by doing a metabolic approach similar to NACHA's approaches. There's higher GLP1, higher GABA and higher glutathione. All super great for reversing cancer and chronic diseases. So I love this. So they improve satiety, reduce inflammation and all of it was statistically associated with the A and the B. So we've thrown a lot of data at you in this first half of the presentation and so I want to just highlight a case that kind of helps you understand how the entire bucket can get so full so fast. So likely a lot of these symptoms up here resonate with you or people that you know or people that you work with in your own practices. But basically this person started in the world with a mom who smoked during pregnancy formula fed allergic to every single formula except for they finally settled on soy. In the future loads of colic this is the patient she talked about with pooping once a month but the pediatrician said that's normal because at least there's you know once a month poopers. I mean it's like they're consistently once a month so somehow that was fine. This person also had a 10 out of 10 ACE score. How many of you here are familiar with the ACE score? Thank you. So that's the adverse childhood events and basically for every over two events before the age of 18 your incidence of having chronic illness or cancer as an adult go up by 20% each one above there. So pretty much a given that that person was going to end up with cancer at some point. And they did three times to be exact before they returned 20 years old. Two of the times related to HPD with cervical cancer so the viral was clearly off and when their stage 4 ovarian terminal diagnosis came at the age of 19 you can tell that the bucket was overflowing with a lot of goo. So important to know this also later on in their lives they found out that they carried the BRCA gene issues which makes them difficult to deal with a lot of methylation processes as well as some issues around comteas snips or the way they dealt with stress and hormones in the world and multiple other factors that we found with functional testing over the years. While I'm on this page I think it's important to point out a few correlations for you to understand how you can take this into your own practices or into yourself. So for instance a history of polycystic ovarian syndrome or fibrocystic breast you have a much higher incidence of ovarian cancer. If you were exposed to second hand smoke even third hand smoke your incidence goes up even higher. The constipation piece related to pretty much all the cancers the ACE scores we've already covered root canals that's a big one start doing your research there BRCA and radiation here's a methylating genetic hiccup that is provoked by more radiation and what do we start doing to this population we radiate them in the ice a year. Please stop smashing and radiating those bony boobs because that will turn on the BRCA mutations that much more. Amalgams all the mercury is driving the glyphosate well it's interacting with the glyphosate driving the oxalates but it also stimulates estrogen in a big big way and if you've got comtea snips and that means you are likely not going to process it very well and store it up it's going to become a proliferator to places in your body that shouldn't be proliferating and then one other piece to highlight about this particular person in the next case we're going to talk about is the undercurrent that I see pretty much a hundred percent of the time in all of my patients dealing with cancer or chronic illness is the deficiency of six main nutrients and that is zinc, selenium magnesium B12, vitamin D and vitamin K2 so guess where I also saw that population those same lab values coming from my vegan and vegetarian patients as well that person was also a long-term vegan and vegetarian at the time she was already three years into that at the time of her terminal diagnosis so these are important things that I wanted you to be thinking about in the bigger picture of what could be in the bucket of the people you're working with and then the next case kind of builds on that it's a very similar parallel case and a lot with other clients the mother had gut issues known gut issues IBS, the birth was unusual a lot of probably likely antibiotics but anesthesia and the case was very healthy until I.B. antibiotics and some steroids although those are probably very helpful and prevented being amputated or something worse so this case is very similar to all my clients courses of antibiotics for UTI colds, acne with dental work surgery long history of Hashimoto's and being overweight and the normal mercury exposure with people have usually several amalgams and testing ended up being at one point of a critical acute health there was IgG testing that was all positive and then standard food allergies in our population I like to have my clients finally challenge their food and usually in four to six months they can start liberalizing or even in one or two months they start liberalizing really quickly especially for oxalates I challenge all my clients to eat gluten and dairy in four to six months because we have probiotics which restores that ability to break down mycotoxins, gluten and casein so this case was really common we see the same SNPs this client had the FUT2 the ATG16L1 SIP1B1 which breaks down estrogen MAO which allows a lot of adrenaline which turns on pathogens in the MTHFR so why we wanted to show you those examples of cases is because a lot of you see them or live with them yourself but we also wanted to show you examples of those cases because you're looking at those two cases right now and so to be standing up here with 25, actually October 21st will be 26 years out from that case history that would be me and understanding how to start playing in my own bucket and start to assess and analyze and change that a lot of that goes back to my naturopathic roots of dealing with the essential determinants of health most of us are not being exposed to the essential determinants of health on a regular basis do you realize just in the 1950s we had an average of four hours a day that we were outdoors today, 15 minutes is the average of how much time we spend outdoors holy cow so when we're indoors what are we under all those crazy lights that are major mitochondrial poisons so I think Dave Asprey calls it the high-fructose corn syrup the light inside our homes these days but these are the types of things we are so disconnected from the natural rhythms of life that part of what I find in the sickest buckets myself included was being more and more and more and further and further and further away from our original ancestral processes that's huge the real dirt on cancer is we need outdoor time and dirt and dirt bacteria and playing in the dirt and allowing our kids to play in the dirt and our pets should play in the dirt so I really want to stress how we can be completely microbial enhanced have superpowers when our microbes are doing everything for us especially if the whole complement is there and we can do that now we have big chunks we can revive them resurrect them I see it in my clients all the time when we do repeat testing or even new biome and the CDSA or GIFX we can see the strains come up again the AB and X so the case earlier was me and I was able to resurrect many strains including the ABCs on oxalates where at one point such a problem a lot of body aches, fibromyalgia lost so collectively 70 I guess but all things are possible the hope from our talk today is just that you are aware that so many solutions are possible right now we have all the tools whether it's mistletoe for as an intervention or mushrooms or protocols everything helps to redirect that terrain and we can reestablish all the populations that back to an ancestral template as they were before without a poop transplant also by the way and part of the microbial metabolites are so protective they come from our food from plants so we are directly connected to plants, Eqal was found to be found in all our bodily fluids so protective for all our gonads brain and organs it comes from a legume and it's microbial enhanced by our gut flora and white mistletoe which Nisha does all the training for I've gone to several of the trainings and I have clients on it it's fermented some of our most powerful brews including ale and beer and kombucha and other powerful foods they're made microbial better and they're preserved as well so these are other things that come from our gut and I think I'm sure you're familiar with a lot of these already but we also can check some of these right now on testing I'd love to share a really amazing story which changed both Nisha's practice and mine I had actually formulated that ultra bifem Maximus are ready prior to this coming out almost as a premonition but this study compared a strong PD-1 drug it's an anti-tumor drug initially for melanoma is everyone familiar with Jimmy Carter and yeah but the drug has a lot of adverse effects including death there's blackbuck warnings, organ failure, colitis, many gut problems they found by putting they had two types of rats mice, teconic rats and Jackson rats and they couldn't tell why the teconic rats were having less efficacy compared to Jax and then when they looked at their gut microbiome they figured out there were 257 different taxa that were different and when they drilled it down they looked at all permutations there was a group of bacteria of Bifido that was 400 times more pronounced in the animals the rodents that actually had tumor regression and this was efficacy as good as a drug with no side effects than the researchers know and when they drilled it further there was a P of 0.0019 and it was a group of Bifido known as Bifidolongum and Bifidobreve and when they co-housed the animals they found that actually this was abrogated you know why? they ate each other's poo so then it got the inferior poo national PD-1 and these strains they actually break down oxalates they protect the gut flora what they found when they tested further is that they induced signals so our bacteria are just like twitter you don't want to screw your twitter you want them totally putting out the right signals and the signals that the Bifidolongum and the breve put out were signals to the lymph nodes so that they would be tumor draining and basically infiltrating like a little pet piranha infiltrating the tumor and erasing it so we have all the tools at our fingertips to actually help chronic disease and cancer and so on max I know we've got about 30 seconds to go on this in those places where foods like or the Bifidom is so huge as a natural PD-1 inhibitor a ketogenic diet is also considered a PD-1 inhibitor a checkpoint inhibitor these are some of the tools that brought restored a lot of my function cleaned out my bucket and that of tens of thousands of the clients I've worked with over the years in some form or fashion so if we could tell about this in the book we could even go into each section of the bucket as its entire own hour and so we're going to kind of flow through these last two because we are over at this point this lies from the website and we've talked about all these pieces of how we're going to get that rhythm restored get the teeter-totter back into balance but to leave you with these thoughts that we are all again biochemically individual emotionally individual epigenetically individual it is so important to assess and address what's going on in that bucket biohack your life folks start with that tube and to learn more please hunt us down we loaded this up with a lot of references to let you just keep going down the rabbit hole here and we'll see you off the break over at the book section thanks so much for attending today that's hard to do it to you right on thank you so much