 the increasingly aging population has resulted in a rise in the prevalence of chronic wounds, CWs. These wounds are characterized by persistent and excessive hyper inflammation, which can be addressed with various immunomodulatory therapies. However, these treatments are often inefficient due to their poor delivery systems. To address this issue, novel immunomodulatory nanotechnologies have been developed to target the immune microenvironment of CWs. These technologies have demonstrated promising results, but there is still much to learn about how they interact with CWs. This review provides an overview of the pathology of CWs, the role of the immune system in wound healing, and the potential applications of immunomodulatory nanotechnologies in the treatment of CWs. It also discusses the challenges and future directions of this emerging field. This article was authored by Xiang Yuqiu, Yuan Xiong, Samuel Nodeler, and others.