 Mycotoxins are secondary metabolites produced by certain types of fungi that can cause serious health issues in animals as well as economic losses. These compounds have been shown to cause growth impairment, decreased resistance to pathogens, hepatotoxicity, nephrotoxicity, and even death. Intestinal cells are the first cells to come into contact with mycotoxins, and they are often exposed to higher concentrations than other tissues. As such, research has focused on how mycotoxins affect intestinal functions, particularly decreasing surface area available for nutrient absorption, modifying nutrient transport, and causing loss of barrier function. Additionally, mycotoxins have been found to facilitate persistence of intestinal pathogens and potentiate intestinal inflammation. On the other hand, the effect of mycotoxins on the intestinal microbiome remains unclear. This review summarizes the current state of knowledge regarding the effects of three common mycotoxins, aflatoxins, acrotoxin A, and fusarium toxins on the intestine. This article was authored by Todd J. Applegate and Bertrand Grainier. We are article.tv, links in the description below.