 It's a good question, and it's evolved, and it evolved throughout the human genome project when we expected that we had somewhere between 100,000 and 200,000 genes. So I don't think we should focus too much on the definition of a gene, I think we should try to sequence as much of the genome as we can and to be able to analyze as much of the genome as we can, and we worry less about the functional definition of a gene, and we worry more about the operational definition of changes, variation, mutations, what have you, and how that sort of plays the phenotype.