 My name is Mazen Oshan and I will talk today about our upcoming publication in stem cells entitled low dose pesticide mixture in uses senescence in human normal mesenchymal stem cells and Tumorogenic phenotype in pre-malignant mesenchymal stem cells We know that hundreds of pesticides are used Worldwide in many domains. One of these domains is agriculture thus fruits vegetables and commodities are contaminated with multiple species of pesticides Even though the quantities of pesticides pesticides students in use in this domain are Regimented not to overpass a limit of human security the exposure of the general population is chronic and is not restricted to one pesticide or one pesticide families the aim of our study was to investigate the effect of mixture of seven pesticides commonly found on food samples and on human mesenchymal stem cells and Addoses that are extrapolated from the levels of pesticide residue found on food samples as reported by the European food safety agency and At the limits of security for humans Human mesenchymal stem cells were treated with a mixture of seven pesticides 21 days later the number of these cells was reduced compared to control cells This was not due to cell death neither by apoptosis nor by autophagy Actually pesticide mixture induced innocence in MSc in a dose dependent manner Our experiences have also shown that this innocence was not telomere dependent, but stress related the pesticide mixture also modified the differentiation potential of MSc favoring adipogenesis rather than osteogenesis In other experiences, we used modified MSc in which stepwise oncogenic hits were Introduced until the stage of premalignancy Once treated with a pesticide mixture for 21 days these cells showed an increased clonal proliferation Moreover, premalignant MSc pre-treated with the pesticide mixture induced initiated high-grade sarcomas when transplanted in mice and this was seen in all the mice In conclusion, we show that a mixture of pesticides that can be ingested on a daily basis may constitute an additional environmental factor favoring aging in normal adult stem cells and Promoting tumorogenesis in pre-disposed stromal environment