 Not a very large number of users that end up in the hospitals but when they do sometimes very severe toxicity with the NPS a lot of the symptoms that bring them in are agitation and aggression and those are the ones in the extreme cases that are most difficult to treat and require large amounts of cetacean quite a lot of resources to contain the user and keep them from hurting others and hurting themselves and in a few cases also death. When responding to a patient that comes in with signs of toxicity and we don't know what kind of NPS they've taken or whether it's an NPS at all we're going to do is the same we do with any of them is treat their signs of symptoms control agitation and control things like hypertension, tachycardia and especially hyperthermia.