 Optoacoustic imaging has been used to explore the vascular environment and morphology of peripheral nerves in healthy volunteers. This technique allows researchers to observe intranural vessels in healthy nerves, which was previously not possible with other imaging techniques. Additionally, the technique can measure the optical contrast of the perfused connective tissue of peripheral nerves, which can be linked to the endogenous contrast of hemoglobin and collagen. These metrics can then be used to analyze the composition of tissue based on its optoacoustic contrast, which can reveal specific differences between nervous tissue and reference tissue in the nerves surrounding. Optoacoustic imaging may provide new insights into the pathophysiology of nerve damage and neuropathies, such as those associated with diabetes. This article was authored by Dominic Justel, Hedwig IRL, Florian Hinterwimmer, and others.