 Cardiovascular diseases are more common in both men and women, but there are differences in clinical symptoms, pathophysiology, and response to treatment. Women tend to have a lower perception of the risk and are often underdiagnosed due to delayed recognition of symptoms. Estrogen provides protection against heart disease during reproductive phase, but after menopause, the risk increases. The presented work highlights the importance of monitoring women's health in their middle age and implementing early intervention strategies to reduce the risk of CVD. This article was authored by Kamila Rixkowska, Veronica Adak, Kamil Janikowski, and others.