 This study investigated the biological activity of Phae-304-Cur at ALG nanoparticle composites in cancer cells and animal models. The results showed that the Phae-304-Cur at ALG nanoparticles are safe and effective for cancer diagnosis and treatment. Specifically, they can enhance the magnetic resonance imaging contrast in cell cultures and tumor-bearing Swiss mice, as well as synergistically inhibit the growth of sarcoma 180 tumors through magnetic heating and the anti-cancer effects of curcumin. Therefore, these Phae-304-Cur at ALG nanoparticles hold promise for future clinical applications. This article was authored by Xian Haidu, 2-DAC Nguyen, T-Thursday Hong Loh, and others.