 This paper examines the concept of sustainability in relation to knowledge translation, KT, practices and health policymaking processes. It draws upon two bodies of literature, health policy and systems research, HPSR, and science and technology studies, STS. The authors argue that sustainability should not be viewed as an end goal but rather as a process of continuous work aimed at making and keeping KT practices productive. They propose three processes, translating, contexting, and institutionalizing, which are necessary for sustaining KT practices. These processes involve building relationships between stakeholders, understanding the context within which KT practices operate, and creating, maintaining, and disrupting institutions to ensure their continued success. This article was authored by Robert A. J. Borst, Rick Warens, and Roland Ball.