 Radionin ARA, a natural compound derived from the plant anemone radiana regal, has been found to be effective at inducing immunogenic cell death, ICD, in tumors, which could potentially improve the effectiveness of immunotherapy treatments. This compound works by binding to a protein called TDP-43, which causes it to accumulate in the mitochondria of tumor cells, resulting in increased production of cyclic GMP-AMP synthase, C-GAS. C-GAS then activates the NFKB pathway, which leads to increased expression of genes involved in antigen presentation and T-cell activation. Combining this compound with an anti-PD1 antibody was also found to increase the effectiveness of immunotherapy treatments in animal models. This article was authored by Ming Xiaoyin, Jing Wendong, Tui Tui's son, and others.