 FDA REMS Assessment and Survey Methodology Highlights Physician Knowledge Attitudes Behaviors, KAB, surveys as regulatory science tools. We reviewed published physician survey response rates, assessed response bias in a simulation study of secondary survey data using different accrual cut-off strategies. The simulation was conducted using secondary data from a population-based physician KAB survey. This article was authored by Sarah E. Brewer, Elizabeth J. Campania and Elaine H. Morato.