 In 2022, there will be 10 key public health challenges that must be addressed. These include the continued threat of COVID-19, insufficient human resources for health, lack of adequate financial support for health systems, conflicts and humanitarian crises, mental health, poverty, climate change, the health of children, reproductive health issues, and the infodemic. These challenges require urgent action and increased investment from governments, civil society organizations, and private sector partners. By focusing on these 10 priority areas, we can make significant progress towards achieving the UN's Sustainable Development Goals.