 This study developed a new type of wound dressing based on polyacrylic acid, PAA, and its derivatives. It was found that the PAA-based coaservate hydrogel had strong wet adhesion capability, which could be attributed to the presence of isoprenyl oxypoly, ethylene glycol, ether and tannic acid. The coaservate also demonstrated excellent antimicrobial activity, promoted fibroblast migration and modulated macrophage polarization. Furthermore, it accelerated healing of full, thickness skin defects and improved collagen deposition, angiogenesis, and epithelialization. This article was authored by Lingxuan Wang, Lianduan, Jia Liu, and others.