 This study proposes a computer-aided diagnosis, CAD, system to distinguish between benign and malignant peripheral pulmonary lesions, PPLs, detected via endobronchial ultrasound, EBU-S. The system achieved an accuracy of 0.7, AF1 score of 0.63, an area under the curve, AUC of 0.75, a positive predictive value, PPV of 0.84, a negative predictive value, and PV of 0.68, a sensitivity of 0.56, and a specificity of 0.85. These results suggest that the proposed CAD system can be used to accurately identify PPLs detected via EBU-S. This article was authored by Hui Al-Wang, Kohei Shikano, Takhiro Nakajima, and others.