 The results of this study showed that the prevalence of helicobacter pylori infection among dyspepsia patients from Majma, Sudair, Zulfi, and Chakra areas of Riyadh region, Saudi Arabia was 34.7%. Majority of patients, 81.7%, had gastritis, out of which, 39.9% of gastritis patients were H. pylori positive. The frequency of H. pylori infection was significantly higher among patients with gastritis, P less than 0.001. There was no statistically significant difference in the frequency of H. pylori infection among patients with erosion, ulcer, polyp and cancer, P greater than 0.05. This article was authored by Talal Shaqzal Ghandi, Tahir Ansari, Adif Ali Bashir and others.