 This study evaluated the prognostic significance of systemic inflammation score, SIS, for patients undergoing video-assisted thoracoscopic surgery, bats, lobectomy for non-small cell lung cancers, nsclcs. The results showed that both overall survival, OS, and disease-free survival, DFS, were significantly shortened with each one point increase in SIS, and SIS equals one and SIS equals two could be independent prognostic factors for unfavorable OS and DFS of nsclcs. Therefore, SIS can serve as a novel risk stratification tool to refine the prognostic prediction for surgical nsclcs. This article was authored by Xuanzhong Li, Wenbyao Zhong, Zhong Yong, and others.