 Cancer formation is a complex process involving multiple intracellular and extracellular stimuli, regulated by specific treatments adapted to each type of tumor and highly dependent on the tumor environment, intracellular molecules, and pathways. Reactive oxygen species, ROS, and autophagy levels play a regulatory role during cancer development from cellular transformation to metastasis, which may serve as potential future therapeutic targets. This article was authored by Laura Poilaporez, Gillis de Spouy, Regis Delage-Maru, and others.