 Hello everyone, welcome back to a new session on oral pathology. So today we have very interesting cells which are peculiar for various diseases. So today's session about few cells that is Anishko cell, Goh cell, Lang hand cells, Langer hand cells and Birbeg granules and also Ashok's bodies. So these are very peculiar characteristics cells which are present in certain diseases and it is very confusing like Lang hands and Langer hand cells. So let's see what is the cells and which diseases which are these are associated with. So the first one is Anishko cell. Anishko cell is a characteristic cell which is seen in rheumatic fever or rheumatic heart disease. So in case of acute rheumatic fever, there is something known as Ashok's bodies are seen in myocardial interstitial. So these bodies are present in the myocardial interstitial space. So which are circumscribed lesion with central focus of necrotic swollen esophilic collagen. So it is a central focus of necrotic swollen esophilic collagen which is surrounded by T. lymphocytes, occasional plasma cells and plumb macrophages. Okay so these are description of Ashok's bodies which is seen in acute rheumatic fever and also in myocardial interstitial. So these macrophages particularly known as Anishko cell. So Anishko cell in detail it is having abundant cytoplasm with central round to avoid nuclei with chromatin is disposed in a central or slenter way. So you can see this is cytoplasm with central round to avoid nuclei with chromatin is disposed in a central and slenter way. That is why it is also known as scatter pillar cells because of its scatter pillar shape of central chromatin. So this is Anishko cell. Anishko cell is present within Ashok's body. So Ashok's body this is a granulomatous tissue. So these are the cells particularly the type of macrophages seen within the Ashok's body is known as Anishko cell and it is characteristics of characteristic feature of rheumatic fever or rheumatic heart disease. So it is also look like all eye in a transverse section. So all eye we have seen in Reed-Steinberg cell which is a characteristic feature of Hodkin's lymphoma. So outside appearance is also seen in Anishko cell but only in transverse section. So it is also known as scatter pillar cells. So sometimes this Anishko cell combine with or coalesce with this Ashok's body becoming Ashok's giant cell. So giant cells are multi nucleated coagulation of various cells. So these two combine and form Ashok's giant cell. So that is Anishko cell which is seen in rheumatic fever or rheumatic heart disease. So just like the Reed-Steinberg cell in Hodkin's disease or Hodkin's lymphoma the various cells which are peculiar to each disease. That is Anishko cell and Ashok's body or scatter pillar cell in rheumatic fever or rheumatic heart disease. Now let's move on to the Go cell. So Go cell are commonly seen in calcifying or endogenic cysts, amyloblastoma, adenomatoid or endogenic tumor or also amyloblastic fibroma. So which is basically a swollen enlarged epithelial cells with esophilic cytoplasm but without a nucleus. It looks like a shadow cell or a translucent cell in H&I staining. So it is having these names that is shadow cell or translucent cell because it is having a shadow appearance. So it looks like a ghost because it doesn't have a proper nucleus. So it is an enlarged balloon or avoid elongated elliptoid cells and it also appear as groups. So it is having abnormal keratinization and few of the cells having little bit of no clear remnants and it is having dystrophic calcification in some cells. So these are the Go cell. It looks like a ghost because it doesn't have a proper nucleus and it also known as shadow cell or translucent cell. And it is commonly seen in calcifying or endogenic cysts, amyloblastoma, amyloblastic fibroma and AOT that is adenomatoid or endogenic tumor. So that is about Go cell. Now let's move on to the Lang Han cells. So never get confused. We have Lang Han cells and Langer Han cells. So this is not very much important here but I just kept to avoid the confusion. So Lang Han cells which are nuclei are arranged. So these cells with nucleus arranged around the periphery in the form of host, shoe or ring. So it is a peculiar arrangement of the nucleus. So it is discovered by Theodor Lang Han. So it is a German pathologist. It is seen in immunogranulomatous inflammation and which are larger. If larger cells with more nuclei, it means there is more virulence. It is nothing but a granular formation, granular formation with the absence of agrocytic activity. So these Lang Han cells which are seen with tuberculosis, the granular maters formation, conditions like tuberculosis, syphilis and sarcoidosis. So these conditions were the peculiar arrangement of nuclei in a host shoe or ring type without any phagocytic activity. And which is seen in granular maters conditions that is Lang Han cells. Whereas Langer Han cells which are dendritic cells which is present in the epidemis. And it contains a peculiar organelles known as Birbe granules. And which is most prominent in the stratum spinosum layer of epidemis. So these cells are seen in mouth, foreskin and it is associated with a particular syndrome that is LCH Langer Han cell histiocytosis when this involves lymph nodes and its basic function is immunity or it is associated with immune system. So these are not particularly associated with any syndrome except it has LCH that is Langer Han cells histiocytosis lymph nodes. But the major things are Anishko cell, Gose cell and Langer Han cells. So we have seen Ashoff's Borees and Anishko cell in rheumatic fever or rheumatic heart disease. Birbe granules in Langer Han cells, Gose cell in calcifying or endogenic cysts, ameloblastoma, ameloblastic fibroma and AOT. And Lang Han cells seen in tuberculosis, syphilis and sarcoidosis. So these are the few cells. So we have studied Stienberg cell and we have many more cells and many more inclusion bodies in pathology. So now let's wind up with this Anishko cell, Gose cell, Lang Han cell and Langer Han cells. This is common questions as for university. So never get confused and always keep in mind. Anishko cell and Ashoff's Boree associated with rheumatic fever, Gose cell. We have four conditions and many more conditions are there. Lang Han cells with tuberculosis, syphilis and sarcoidosis and Langer Han cells. It is a dendritic cells seen in stratum spinosum with Birbe granules. So I will come up with a new topic in oral pathology. Thank you.