 We have developed and optimised a time and cost-effective massive parallel sequencing workflow for diagnostic genetic testing of mismatch repegents. Cholorectal cancer is the third most common cancer in the world with over 1.2 million new cases each year. Most of these cases are non hereditary, while 20-25% have a familial predisposition or hereditary syndrome with a lifetime risk of up to 60-80% of developing cancer. A mutation in one of the mismatch repegents is the cause of Lynch syndrome, which is the most common hereditary cholorectal cancer syndrome. It is very important to identify individuals with increased genetic risk in order to include them in regular examinations. This is to remove early precursors of cancer, and of course to reduce the mortality in this patient group. Here at St. Olaf's University Hospital, we have performed diagnostic genetic testing of mismatch repegents for 10 years. Until now, we mainly relied on cancer sequencing to detect mutations. However, this method is both expensive and time-consuming. Also, the increasing demand for genetic testing, combined with the request for shorter sample turnaround times, required a more effective sequencing technology. Therefore, we developed an ampicon-based Massive Parallel Sequencing Method, and only minor changes to our original Sanger Sequencing Setup was necessary to make it compatible with the new Massive Parallel Sequencing Workflow. This method is now well established here at the hospital's medical genetics laboratory, and it enables us to offer genetic testing to more patients faster and cheaper without compromising sensitivity. Since 2005, we have seen a rapid development in DNA sequencing technology. We anticipate that Nanopore and third-generation sequencing technology will further accelerate genetic testing while maintaining low costs. We are excited to see what your future holds in the field of DNA sequencing technology. If you want to know more about this work, we invite you to read our manuscript in Molecular Genetic and Genomic Medicine. Thank you for your attention and happy reading!