 There is limited data on within host SARS-CoV-2 genetic diversity and how it is affected by vaccination. The authors analyzed intra-host sequence diversity and found that VOX may have more sequence variations than non-VOCS and that breakthrough infections in vaccinated individuals do not seem to increase non-silent mutations. This article was authored by Hao Gao-Giu, Ahmed Abdul Qaeda, Pavitra Krishnan, and others.