 Dental caries is a chronic infectious disease caused by the invasion of oral bacteria into the teat's enamel and dentin. The bacterial infection triggers inflammatory responses in the dental pulp, which can lead to pulp healing if the infection is not too severe. However, chronic inflammation often persists in the pulp despite treatment, leading to permanent damage and reduced ability for the pulp to heal. To prevent further damage, it is important to create a reactionary, repetitive dentin barrier to protect the pulp from infectious agents and restorative materials. This paper discusses how this barrier forms as a result of the pulp's response to bacteria, and how it can be used to promote the resolution of pulp inflammation and restore tissue homeostasis. This article was authored by Jean-Christophe Fages, Brigitte Alliot-Lect, Emmanuel Renaud, and others.