 This study examined the presence of aerobic bacteria, antibiotic resistance, and multi-drug resistance profiles of bacteria isolated from various wound infections among a group of Egyptian patients. The results indicated that polymicrobial infections were present in 55% of samples, with Staphylococcus aureus being the most common cause of wound infections due to accidents. The prevalence of methicillin-resistant S. aureus was high at 89.9%, while Pseudomonas originosa was found to be highly sensitive to Suprafloxacin but highly resistant to Levofloxin. Additionally, several isolates displayed a multi-drug resistance profile, indicating a need for improved hygiene practices and health education strategies to reduce the risk of wound infections caused by these organisms. This article was authored by Iman Farooq Ahmed, Aisha Helmi-Rasmi, Aptu M. A. Darwish, and others.