 This study has developed five olfaxinographed models of malignant peripheral nerve sheath tumours, MPNSTs, from patients with neurofibromatosis type 1, NF1, and sporadic cases. The models accurately replicate the histology and behaviour of the original tumours, including the ability to spread to distant sites in mice. Additionally, the models have been used to test various drugs for efficacy against MPNSTs, providing valuable insight into potential treatments for this rare cancer. This article was authored by Joan Castelsaig, Benette Gell, Juana Fernandez Rodriguez, and others.