 Sleep deprivation, SD, can cause significant damage to memory processes in rodents. Studies have shown that SD causes impairments in synaptic plasticity, neuronal injury, oxidative stress, and neurotransmitter levels. These changes are thought to be responsible for the negative impacts of SD on memory. However, there is still much to learn about how these mechanisms interact and what the best solutions may be. This review paper provides a comprehensive overview of current research on the topic, highlighting key findings and suggesting potential solutions. This article was authored by Ping Xiu Chen, Wei Kong Ban, Wen Yan Wang, and others.