 Zoonotic diseases are inherently caused by motorhost pathogens, thus incorporating humans and other animal hosts, the environment in which transmission takes place is key to understanding and controlling them. Indeed, 60% of all infectious diseases have more than one host and 75% of new emerging human infectious diseases are defined as zoonotic, meaning they may be naturally transmitted from vertebrate animals to humans. It's thus very important to examine health effects across species in order to fully understand the health and economic impact of such pathogens and to help implement treatment and preventive programs. This is what one health is all about. First, most zoonotic diseases do not exhibit symptoms in both humans and animals. This is further compounded by lack of easy to use and cheap diagnostic tests. Secondly, there is lack of cooperation between veterinary institutions and human health institutions in tackling zoonosis challenge. The diseases have uncanny ability to emerge anywhere and spread rapidly, both locally and globally. Thirdly, there is continued neglect of many zoonosis in the disease prioritization processes of many developing countries. There is urgent need to build one health capacity regionally and foster close cooperation between veterinary and medical field in tackling the zoonosis challenge. There is also need to strengthen surveillance systems, including integrating zoonosis in the existing systems and increasing investment in zoonosis prevention programs such as vaccination and mass drug administration.