 The current study describes a suppository base composed of aqueous gelatin solution emulsifying oil globules with probiotic cells dispersed within. The gelatin oil probiotic suppository showed uniformity in weight and probiotic content, 23 plus or minus 2.481 by 108 CFU, with favorable swelling, double, followed by erosion and complete dissolution within 6H of administration. This article was authored by Anchol Basi, Garima Sharma, Parnit Kordale and others.