 The review discusses the distribution and treatment of soft tissue sarcoma. Approximately 10,000 new patients are registered in Russia each year, with a rate of 30 cases per 1 million populations. Soft tissue sarcoma typically affects people aged between 56 and 65, with a peak in those aged over 80. There are over 100 different types of soft tissue sarcoma, including undifferentiated sarcomas, liposarcomas, liomyosarcomas, synovial sarcomas, and malignant tumors of peripheral nerve membranes. Diagnosing these cancers requires both traditional histopathology and immunohistochemistry or molecular testing. To improve the accuracy of diagnosis, the World Health Organization recommends complementing traditional histopathology with additional tests. Another approach to treating soft tissue sarcoma is called oncology control, which involves reducing the risk of recurrence at both the local and systemic levels. This article was authored by V. V. Benbran, B. T. Bezikov, N. A. Shnazarov, and others. We are article.tv, links in the description below.