 This study examined how mesenchymal stem cell, MSc, derived exosomes can be used to reduce inflammation caused by burns. The researchers found that burns increase the production of pro-inflammatory cytokines such as TNF-alpha and IL-1-beta while reducing anti-inflammatory cytokine IL-10. They also discovered that these effects are mediated by microRNA, MyRNA-181c, which is present in MSc-derived exosomes. When administered to burn victims, MyRNA-181c, containing exosomes were able to reduce inflammation by down-regulating the toll-like receptor IV, TLR4, signaling pathway. This suggests that MSc-derived exosomes may be a promising therapeutic option for treating burn injuries. This article was authored by Xiaoli, Lingying Lu, Jingyang, and others.