 Skin protects the body from external substances and functions as a barrier to fluid loss and trauma, comprising of epidermal, dermal and hypodermal layers with different cell types embedded on extracellular matrix. When skin integrity is compromised due to injury, skin substitutes are used for wound coverage with different kinds available such as a cellular, cultured epidermal cells, dermal components or tissue engineered substitutes. Fibrosis is a common feature of post burn wounds and can cause cosmetic and functional problems. Dermal fibroblasts are heterogeneous with superficial and deep fibroblasts having different properties that may affect post burn wound healing. Selective use of superficial dermal fibroblasts may be beneficial for post burn wound healing. This article was authored by Matthew Varky, Jedding and Edward E. Tregit.