 This study reports on a database surveillance of vaccine-related clinical trials conducted in Africa, with the aim of profiling and addressing vaccine clinical trials in the region. The study found that 61% of the 377 trials were registered prospectively, with most trials being single-country studies within the country. Industry was the biggest funder of the vaccine trials, while malaria was the most studied disease. The conduct of vaccine clinical trials in Africa seeks to address the disease epidemics faced by the continent and there is a need for more investments from governmental bodies toward vaccine research in Africa. African country collaborations are also needed to find African solutions to current infectious disease threats. This article was authored by Jujul N. Buandwe, Kopano Jub, Lindy Mithibula, and others.