 The abstract mammalian target of rapamycin, MTOR, regulates cell proliferation, autophagy, and apoptosis through multiple signaling pathways and is associated with various diseases including cancer, arthritis, insulin resistance, osteoporosis. MTOR inhibitors are a hot target in antitumor therapy research, with many newly discovered drugs entering clinical studies and showing high activity in combination with MTOR inhibitors. This article was offered by Sulin Tzu, Tao Tao, Hong Mei Li, and others.