 Models of insulin secretive vesicles from pancreatic beta cells have been constructed using the CELP-ACK suite of tools. These models integrate experimental data from proteomics, structural biology, cryo-electron microscopy and x-ray tomography. A new method was developed to reconcile inconsistencies between these different datasets by combining expert annotations with computational analysis. This allowed for the generation of soft x-ray tomograms, which can be used to interpret experimental tomograms at the molecular level. This article was authored by Ludovic Orting, Brete Barbaro, Andrew I. Dewitt, and others.