 Thank you very much and thank you for the generous support to the Brain Foundation and its donors and supporters and to the committee itself. I'm a first-year PhD student at the Neuroscience Department at Monash University in Melbourne, and I work as an epilepsy fellow at the Alfred Hospital. I also wanted to acknowledge my supervisors, Terri O'Brien, Patrick Kwan, as well as Pierra Peruca. So my research really focuses around the development of epilepsy, which is as also known by the term of epileptogenesis. Three to five percent of Australians suffer from epilepsy and 30 percent don't respond to any treatment. All of the treatment that we have at the moment is to prevent further seizures, but doesn't actually address the overarching principles of why epilepsy is developed in the first place. So I'm interested in working out how the brain changes over time from being a normal brain to a brain that develops into a proponency to have seizures. So how can we observe this process? 40 to 50 percent of patients with severe traumatic brain injury develop post-traumatic epilepsy down the track. And this is really defined as seizures after the first week of their admission. As you would expect, patients with severe traumatic brain injury require hospital care in the form of ICU treatment. And for this reason, there is an observable period for these patients that we can monitor them before they develop epilepsy. So I'm going to be looking at clinical factors, some of which that are known, biological imaging and genetic factors, but specifically the EEG, the electrophysiology behind the brain activity that is going on in these patients prior to their first seizure and then subsequently epilepsy. 20 to 30 percent of patients in this first week are having seizures and we don't quite understand what the implications are for these patients with those type of seizures down the track. I was able to spend a week at UCLA Hospital in Los Angeles and witnessed that in America they have EEG monitors in the ICU. They have a typical unit of 25 beds and there will be 25 monitored units with EEG continuously and just like blood pressure or heart rate. In Australia, we don't have the capability and I've addressed in my project that this is an unmet clinical need within the Australian ICU community. We know that the seizures in the ICU do cause significant damage. It's been some studies from UCLA that show that there's a metabolic crisis that happens in the brain after these seizures because there's an unmet need for energy in the brain as the seizure exceeds the requirements of the brain at that time. So it's thought that these seizures cause secondary injury and subsequent damage to patients and further compound their injuries after their original traumatic brain injury. Questions are really secondary to look at this continuous monitoring in Australia and see if it's feasible and see if we can potentially use this modality to suppress seizures with the hope that they may actually prevent patients from developing epilepsy down the track. So with the generous funding from the Brain Foundation I aim to investigate the factors that cause epilepsy and explore this technique in Australia for the very first time which is not being used here to see if we can further add to the treatment of these patients. So thank you once again and for the generous support. It's very much appreciated.