 UV-sensitive syndrome, UVSS, is a rare skin condition characterized by a variety of symptoms such as freckles, telangiectasias, and severe sunburns. It is inherited in an autosomal recessive manner and has been reported in nine different countries. The exact prevalence is unknown, but estimates suggest that it occurs at a rate of 1,100,000 globally. Three genes have been identified as being associated with UVSS, including ERCC6, ERCC8, and UVSSA. UVSSA is most commonly found in people of Pakistani descent. Physiologically, UVSS genes are involved in the transcription-coupled nucleotide excision repair pathway. Treatment for UVSS includes avoiding direct exposure to the sun, wearing protective clothing, and using topical medications. This article was authored by Mohamed Muzamal, Mohamed Zishan Ali, Safira Mad, and others. We are article.tv, links in the description below.