 The extracellular matrix, ECM, plays a critical role in many biological processes such as development, wound healing, and organ homeostasis. When ECM remodeling becomes excessive or uncontrolled, it can lead to life-threatening pathological conditions like fibrotic diseases and cancer. These conditions are responsible for over 45% of deaths in the developed world. To better understand and treat these diseases, researchers have used various methods and models to study ECM remodeling. These include in vitro and in vivo models, as well as technologies that allow for accurate monitoring, imaging, and quantification of the ECM. By using these tools, researchers hope to gain a deeper understanding of ECM remodeling and its role in fibrotic diseases and cancer, leading to improved diagnosis and treatment options. This article was authored by Thomas Acox and Janine Tiella.