 This study investigated the use of a novel type of electrocatalyst consisting of ruthenium nanoclusters, RuSNCs, supported on W18049 nanowire, NW. The RuSNCs were found to be anchored to the W18049 NWs by RuOW bonds, resulting in a strong metal support interaction. This interaction was further enhanced by the presence of oxygen vacancies in the W18049 NWs, which provided a pathway for protons to migrate through the material. The combination of these two factors resulted in a highly active electrocatalyst, with superior performance compared to other materials. This article was authored by Yetzan Pi, Zimmin Chiu, Yi Sun, and others.