 MicroRNAs, HIST-MIRNAs, are small regulatory non-coding RNAs that negatively regulate gene expression and play a vital role in tumor initiation, progression, and metastasis. They have emerged as promising therapeutic tools for cancer management, with ongoing evaluation of ME RNA-based strategies for use in the clinic. This article was authored by Matri Y. Shaw, Alessandra Farajoli, Anil K. Sud and others.