 This study found that synovial fluid levels of two proteins, fibrinogen beta chain, FBG, and alfinolease 1, EN01, were significantly higher in patients with severe osteoarthritis, OA, than in healthy controls. Furthermore, there was a strong correlation between these protein levels and clinical scores in patients with OA. These findings suggest that these proteins may be useful biomarkers for predicting the severity of OA. This article was authored by Maria Teresa Raquetti, Davide Bazzocca, Lorenzo Moretti, and others.