 Abstract, we measured concentrations of SARS-CoV-2, influenza A and B virus, respiratory syncytial virus, ISV, Mpox virus, human metapumamovirus, norovirus GII, and peppermild model virus nucleic acids in wastewater solids at 12 wastewater treatment plants in central California, USA. Measurements were made daily for up to two years, depending on the wastewater treatment plant. Measurements were made using digital droplet, reverse transcription, polymerase chain reaction, RT-PCR, following best practices for making environmental molecular biology measurements. These data can be used to better understand disease occurrence in communities contributing to the wastewater. This article was authored by Alexandria B. Berm, Marlene K. Wolfe, Christa R. Wigginton, and others.